Dissemination of the mcr-1 colistin resistance gene
نویسندگان
چکیده
منابع مشابه
Dissemination and Mechanism for the MCR-1 Colistin Resistance
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomi...
متن کاملglobal dissemination of the mcr-1 gene
antimicrobial resistance is one of the most severe threats to human health. the first report of plasmid-mediated colistin resistance in escherichia coli from animals, food, and humans was in 2015 from china. the current increasing trend of resistance is extremely troubling because polymyxins are the last-resort antibiotics for treating infections with carbapenem-resistant enterobacteriaceae.
متن کاملFeatures of the mcr-1 Cassette Related to Colistin Resistance.
Katrin Zurfluh, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann, Roger Stephan Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Switzerland; Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (LEA Paris, France), University of Fribourg, Fribourg, Swi...
متن کاملDeciphering MCR-2 Colistin Resistance
Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem-resistant bacteria. Very recently, a new plasmid-borne colistin resistance g...
متن کاملThe Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)
Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ec...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2016
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(16)00063-3